Vortioxetine

Indications & formulation #

Major depressive disorder in adults. This reference covers the selected formulation; other indications and products need their own evidence.

Dose reference #

Adult educational reference · Oral tablet · United States. The clinician selects treatment after assessment; this page does not calculate or change a prescription.

Start 10 mg/day; increase to 20 mg/day as tolerated. Consider 5 mg/day if higher doses are not tolerated.

Contraindications & important cautions #

Avoid MAOIs: at least 14 days after an MAOI and 21 days after vortioxetine before an MAOI. Review serotonin toxicity.

Selected important cautions; consult the full product information for all contraindications and warnings.

Adverse effects #

Nausea and sexual effects, activation and other serotonergic cautions require individual review.

Interactions #

CYP2D6 inhibitors/inducers and serotonergic combinations can alter exposure or adverse effects.

Monitoring #

Review target symptoms, function, tolerability and interactions; a multimodal mechanism does not guarantee cognitive improvement.

Special populations #

CYP2D6 poor metabolizers: maximum 10 mg/day. Strong CYP2D6 inhibitors require halving the dose.

Adult scope. Pregnancy, breastfeeding and pediatric use require the exact product’s population-specific guidance and individual assessment.

Discontinuation, restarting & counseling #

For 15–20 mg/day, the label recommends 10 mg/day for one week before stopping.

Brands & products #

Reference coverage #

Structured summary of selected adult uses, not an exhaustive monograph. Indian product authorization and local prescribing requirements have not been reconciled.