Varenicline

Indications & formulation #

Smoking cessation in adults; not nasal dry-eye treatment. This reference covers the selected formulation; other indications and products need their own evidence.

Dose reference #

Adult educational reference · Oral tablet · United States. The clinician selects treatment after assessment; this page does not calculate or change a prescription.

Days 1–3: 0.5 mg daily; days 4–7: 0.5 mg twice daily; then 1 mg twice daily. Standard course 12 weeks with behavioral support.

Contraindications & important cautions #

Review nausea, sleep effects, seizures and significant mood/behavior changes. Serious hypersensitivity/skin reactions require assessment.

Selected important cautions; consult the full product information for all contraindications and warnings.

Adverse effects #

Nausea, vivid dreams and sleep disturbance.

Interactions #

Renal clearance affects dosing; review alcohol-related effects.

Monitoring #

Monitor quit progress, mood/behavior, sleep and renal function where relevant.

Special populations #

CrCl below 30: start 0.5 mg/day, maximum 0.5 mg twice daily; hemodialysis maximum 0.5 mg/day if tolerated.

Adult scope. Pregnancy, breastfeeding and pediatric use require the exact product’s population-specific guidance and individual assessment.

Discontinuation, restarting & counseling #

Review abstinence and relapse prevention at course completion; an additional course may be appropriate after successful cessation.

Brands & products #

Reference coverage #

Structured summary of selected adult uses, not an exhaustive monograph. Indian product authorization and local prescribing requirements have not been reconciled.