Naloxone

Indications & formulation #

Emergency treatment of suspected opioid overdose. This reference covers the selected formulation; other indications and products need their own evidence.

Dose reference #

Adult educational reference · REXTOVY intranasal 4 mg single-dose device · United States. The clinician selects treatment after assessment; this page does not calculate or change a prescription.

Give one spray and obtain emergency medical help. Use a new device for each repeat dose; repeat at 2–3-minute intervals if needed while supporting breathing and monitoring.

Contraindications & important cautions #

Recurrent respiratory depression may outlast naloxone. Acute withdrawal can occur; response does not establish lasting safety.

Selected important cautions; consult the full product information for all contraindications and warnings.

Adverse effects #

Acute withdrawal and recurrence of respiratory depression.

Interactions #

Long-acting or potent opioids may require repeated reversal and prolonged monitoring.

Monitoring #

Continuously assess breathing, consciousness and need for emergency support.

Special populations #

Emergency care and observation remain necessary in all populations. Do not extrapolate this device dose to injectable formulations.

Adult scope. Pregnancy, breastfeeding and pediatric use require the exact product’s population-specific guidance and individual assessment.

Discontinuation, restarting & counseling #

Do not leave the person alone after response. Arrange continuing overdose prevention and treatment linkage.

Brands & products #

Reference coverage #

Structured summary of selected adult uses, not an exhaustive monograph. Indian product authorization and local prescribing requirements have not been reconciled.