Lurasidone

Indications & formulation #

Schizophrenia in adults; separate bipolar-depression range. This reference covers the selected formulation; other indications and products need their own evidence.

Dose reference #

Adult educational reference · Oral tablet with a meal of at least 350 calories · United States. The clinician selects treatment after assessment; this page does not calculate or change a prescription.

Schizophrenia: start 40 mg/day, range 40–160 mg/day. Bipolar depression: start 20 mg/day, range 20–120 mg/day. Food is essential for exposure.

Contraindications & important cautions #

Strong CYP3A4 inhibitors and inducers are contraindicated. Review akathisia, movement symptoms and sedation.

Selected important cautions; consult the full product information for all contraindications and warnings.

Adverse effects #

Akathisia, nausea, somnolence and movement symptoms.

Interactions #

CYP3A4 inhibitors/inducers materially alter exposure.

Monitoring #

Review food intake with dosing, movements, metabolic measures and tolerability.

Special populations #

Moderate/severe renal or hepatic impairment requires lower starting doses and ceilings; severe hepatic disease has the lowest ceiling.

Adult scope. Pregnancy, breastfeeding and pediatric use require the exact product’s population-specific guidance and individual assessment.

Discontinuation, restarting & counseling #

Reassess before reduction or switching; do not extrapolate schizophrenia doses to bipolar depression.

Brands & products #

Reference coverage #

Structured summary of selected adult uses, not an exhaustive monograph. Indian product authorization and local prescribing requirements have not been reconciled.